Ipa Ti Nṣiṣẹ Nrf2

Ọpọlọpọ awọn iwadi iwadi ti o lọwọlọwọ lori akàn ti gba awọn oṣoogun ilera lati ni oye nipa ọna ti ara ṣe nyọ. Nipa gbigbasilẹ awọn ikun ti a ti ni awọn awọ ti o wa ni awọn ẹyin ti o tumọ si, awọn oluwadi ṣawari Idagbasoke 2 ọna asopọ ti o niiṣan ti ipasẹ iparun, ti a mọ julọ bi Nrf2. NRF2 jẹ ẹya pataki transcription eyiti o mu ki ara eniyan ṣiṣẹ awọn eto idena ipanilaya lati le ṣe atunṣe ifẹdidọ lati awọn ti ita ati awọn ohun inu inu lati dena awọn ipele ti o pọju wahala ti o ni agbara.

Awọn Agbekale ti Nrf2

NRF2 jẹ pataki si mimu ilera ati ilera gbogbogbo nitori pe o ṣojuuṣe idi akọkọ ti ṣiṣakoso bi a ṣe ṣakoso ohun gbogbo ti a farahan si ni ojoojumọ ati pe a ko ni aisan. Ṣiṣẹ NRF2 n ṣe ipa ninu eto detoxification alakoso II. Phase II detoxification gba lipophilic, tabi tio tilẹ solfat, awọn ipilẹṣẹ ọfẹ ati yi wọn pada sinu hydrophilic, tabi olomi tiotuka, ti alakoso I.

Nisẹjẹẹ NRF2 n dinku ifasimu ati igbona ti ara eniyan nipasẹ ipa ibanuje. Lati nfa NRF2, ipalara ikun ti ajẹsara nitori pe o yẹ ki o wa ni isunmi ni ibere fun awọn sẹẹli lati ṣe idahun ti n ṣe afẹfẹ ati ki o ṣẹda awọn ẹda ara, gẹgẹ bi awọn glutathione. Lati ṣẹgun opo ti Nrf2, pataki, iṣeduro oxidative n mu NRF2 ṣiṣẹ eyiti o mu ki idahun idaamu ni ara eniyan ṣiṣẹ. NRF2 awọn iṣẹ lati dọgba idiyele redox, tabi iwontunwonsi ti oxidant ati awọn ipele antioxidant ninu cell.

Apejuwe nla ti bii awọn iṣẹ ilana yii le ṣe afihan pẹlu adaṣe. Nipasẹ gbogbo adaṣe, iṣan naa ṣe adaṣe ki o le gba igba adaṣe miiran. Ti NRF2 ba wa labẹ- tabi ju-ṣalaye nitori awọn akoran onibaje tabi ifihan ti o pọ si awọn majele, eyiti o le ṣe akiyesi ni awọn alaisan ti o ni aarun idaamu iredodo onibaje, tabi CIRS, awọn ọran ilera le buru si lẹhin titẹsi NRF2. Ju gbogbo rẹ lọ, ti DJ-1 ba di alaabo pupọ, ifisilẹ NRF2 yoo pari ni kiakia.

Awọn ipa ti NRF2 Nṣiṣẹ

Nisẹjẹẹ NRF2 ti wa ni gíga han ninu ẹdọforo, ẹdọ, ati awọn kidinrin. Nkan 2 ti o ni nkan ti o niiṣiro ipilẹ nkan ti o ni ipilẹ 2, tabi NRF2, awọn iṣẹ ti o wọpọ julọ nipa gbigbeku awọn ipele ti o pọju ti iṣelọdu ninu ara eniyan ti o le mu ki wahala ti o ni agbara. Nisẹjẹẹ Nrf2 le ṣe iranlọwọ lati ṣe abojuto awọn orisirisi awọn oran ilera, sibẹsibẹ, iṣeduro diẹ Nrf2 le mu awọn iṣoro ti o pọ sii, eyiti a ṣe afihan ni isalẹ.

Igbesẹ ti igbagbogbo ti Nrf2 le ran:

• Agbo (ie Ilọ)
• Aifọwọyi ati Iwoye igbona (ie Arthritis, Autism)
• Akàn ati Chemoprotection (ie EMF ifihan)
• Ibanujẹ ati Ẹtan (ie PTSD)
• Ofin Drug (Ọti, NSAIDs)
• Idaraya ati Iṣiro Itọju
• Arun Gut (ie SIBO, Dysbiosis, Ulcerative Colitis)
• Àrùn Arun (ie Irẹjẹ Àrùn Àrùn, Àrùn Àrùn Àrùn, Lupus Nephritis)
• Arun Ẹdọ (ie Arun Ọti Ẹmu, Ẹdọ Aisan Tigun, Àìjẹ Ẹjẹ Nonalcoholic, Ẹjẹ Nonalcoholic Steatohepatitis, Cirrhosis)
• Arun Ẹdọ (ie Asthma, Fibrosis)
• Ibaramu ati Ẹjẹ Vascular (ie Atherosclerosis, Haipatensonu, Ẹgun, Àtọgbẹ)
• Neurodegeneration (ie Alzheimer's, Parkinson's, Huntington's ati ALS)
• Irora (ie Neuropathy)
• Awọn iṣọn-awọ (ie Psoriasis, UVB / Sun Protection)
• Àfihàn Toxin (Arsenic, Asbestos, Cadmium, Fluoride, Glyphosate, Mercury, Sepsis, Ẹfin)
• Iran (ie Imọlẹ Bright, Sensitivity, Cataracts, Dnestrophy Cone)

Hyperactivation ti Nrf2 le buru sii:

• Atherosclerosis
• Akàn (ie ọpọlọ, igbaya, Ori, Ọrun Pancreatic, Ọfẹ, Ẹdọ, Thyroid)
• Onibajẹ Idahun Ẹdun Irẹdanu (CIRS)
• Iṣipọ Ọkàn (lakoko ti o ṣi NRF2 ṣile jẹ buburu, NRF2 le ṣe iranlọwọ pẹlu atunṣe)
• jedojedo C
• Awọn Nasitisi (awọn iṣẹlẹ nla)
• vitiligo

Pẹlupẹlu, NRF2 le ṣe iranlọwọ ṣe awọn afikun awọn ijẹẹmu ni pato, awọn oogun, ati awọn oogun ṣiṣẹ. Ọpọlọpọ awọn afikun awọn ohun alumọni le tun ṣe iranlọwọ fun okunfa NRF2. Nipasẹ awọn iwadii iwadii lọwọlọwọ, awọn oniwadi ti ṣe afihan pe nọmba nla ti awọn agbo ogun eyiti a gbagbọ lẹẹkan si pe awọn antioxidants jẹ pro-oxidants gaan. Iyẹn nitori pe fere gbogbo wọn nilo NRF2 lati ṣiṣẹ, paapaa awọn afikun bi curcumin ati epo eja. Koko, fun apẹẹrẹ, ni a fihan lati ṣe ina awọn ipa ẹda ara ninu awọn eku eyiti o ni pupọ pupọ NRF2.

Ona Lati Mu NRF2 ṣiṣẹ

Ninu ọran ti aisan ti ko ni ọkan bi arun Alzheimer, aisan Arun Parkinson, aisan tabi paapaa awọn aiṣedede autoimmune, o ṣee ṣe julọ lati ni Nrf2 upregulated, ṣugbọn ni ọna iṣanju. Ṣiṣẹpọ awọn activators NRF2 tun le ni ipa iyokuro tabi iṣiro, bi lẹẹkọọkan o le jẹ igbẹkẹle-iwọn-ara. Awọn ọna oke lati mu Nrf2 ikosile han ni isalẹ:

• HIST (Idaraya) + CoQ10 + Sun (wọnyi synergize pupọ daradara)
• Broccoli Sprouts + LLLT lori ori mi ati ikun
• Butyrate + Super Coffee + Morning Sun
• Acupuncture (eyi jẹ ọna miiran, išẹ-ilọ-ta-a-la-le-ni laser le tun ṣee lo)
• Ãwẹ
• Cannabidiol (CBD)
• Mane + Melatonin kiniun
• Alpha-lipoic acid + DIM
• Wormwood
• PPAR-gamma Activation

Atẹle kikojọ ti o ni lori 350 awọn ọna miiran lati mu Nrf2 ṣiṣẹ nipasẹ ounjẹ, igbesi aye ati awọn ẹrọ, awọn ohun elo, awọn afikun, awọn ewebe ati awọn epo, awọn homonu ati awọn neurotransmitters, awọn oògùn / oogun ati awọn kemikali, awọn ọna / awọn itọnisọna transcription, ati awọn ọna miiran, nikan itọsọna kukuru kan si ohun ti o le fa Nrf2. Fun idi ti aṣiṣe ninu ọrọ yii, a ti fi awọn ounjẹ miiran 500 silẹ, awọn afikun ounjẹ ounjẹ ati awọn agbo ogun ti o le ran Nrf2 ṣiṣẹ. Awọn wọnyi ti wa ni akojọ si isalẹ:

Onjẹ:

• Acai Berries
• Ọtí (Ọti-waini ti o dara julọ, paapa ti o ba wa ni koki ninu rẹ, bi awọn protocatechuic aldehyde lati awọn corks tun le mu NRF2 ṣiṣẹ. Ni apapọ, a ko ṣe agbero ọti-baramu, biotilejepe awọn gbigbe ikun ti nyara NRF2.
• Algae (kelp)
• apples
• Black Tii
• Brazil awọn eso
• Awọn Sprouts Broccoli (ati awọn miiran isothiocyanates, sulforaphane ati awọn ẹfọ cruciferous bi bok choy ti o ni D3T)
• Blueberries (0.6-10 g / ọjọ)
• Karooti (falcarinone)
• Cayenne Ata (Capsaicin)
• Seleri (Butylphthalide)
• Chaga (Betulin)
• Chamomile Tea
• chia
• Ọdun Ọdun Ọdun
• Chokeberries (Aronia)
• Chocolate (Dudu tabi koko)
• Epo igi
• Kofi (bii chlorogenic acid, Cafestol ati Kahweol)
• Cordyceps
• Eja (ati ẹiyẹ)
• flaxseed
• Ata ilẹ
• Ghee (ṣee ṣe)
• Atalẹ (ati Cardamonin)
• Gojiberries
• Eso ajara (Naringenin - 50 mg / kg / d naringenin)
• Àjara
• Green tii
• Guava
• Okan Ọpẹ
• Hijiki / Wakame
• Honeycomb
• KIWI
• Awọn Legumes
• Kiniun Kiniun
• Mahuwa
• Mangos (Mangiferin)
• Mangosteen
• Wara (ewúrẹ, Maalu - nipasẹ ilana ti mimuro-oyinbo)
• Mulberries
• Epo Olifi (Pomace - hydroxytyrosol ati Oleanolic Acid)
• Omega 6 Fatty acids (Lipoxin A4)
• Osange Oranges (Morin)
• Awọn ohun ọti oyinbo
• papaya
• peanuts
• Eso Pigeon
• Pomegranate (Punicalagin, Ellagic Acid)
• Propolis (Pinocembrin)
• Ekan ti o dara ti o dara
• Rambutan (Grani)
• Alubosa
• Reishi
• Rhodiola Rosea (Salidroside)
• Rice Bran (cycloartenyl ferulate)
• Riceberi
• Rooibos tii
• Rosemary
• Sage
• Safflower
• Epo Sesame
• Soy (ati isoflavones, Daidzein, Genistein)
• Elegede
• strawberries
• Tartary Buckwheat
• Thyme
• tomati
• Awọn ẹwẹ Tonka
• turmeric
• Wasabi
• Elegede

Igbesi aye ati Awọn Ẹrọ:

• Acupuncture ati Electroacupuncture (nipasẹ apọn oju omi oju omi lori ECM)
• Ina bulu
• Awọn Ẹrọ Brain (mu NRF2 ni hippocampus)
• Ihamọ Caloric
• Tutu (oju ojo, irọra, yinyin wẹ, jia, cryotheraphy)
• EMF (igbohunsafẹfẹ kekere, gẹgẹbi PEMF)
• Idaraya (Idaraya nla bi HIST tabi HIIT dabi pe o ni anfani diẹ sii fun fifa NRF2, lakoko ti adaṣe to gun ko ni fa NRF2, ṣugbọn o mu awọn ipele glutathione pọ si)
• Agbara Ọra Diet (onje)
• Opo giga (Sauna)
• Isinmi Agbara ati Imi Agbara
• Hyperbaric Oxygen Therapy
• Itọju ailera infurarẹẹdi (bii Joovv)
• Vitamin C ti o ni inu didun
• Ketogenic Diet
• Ozone
• Mimu (ko ṣe iṣeduro - mugagagagaga nmu NRF2 soke, sisun siga ti n dinku NRF2 Ti o ba yan lati mu siga, Basil mimọ le ṣe iranlọwọ fun idaabobo lodi si isodi-ofin ti NRF2)
• Oorun (UVB ati infurarẹẹdi)

Awọn apẹrẹ:

• Bacillus subtilis (fmbJ)
• Clostridium butyricum (MIYAIRI 588)
• Lactobacillus brevis
• Lactobacillus casei (SC4 ati 114001)
• Lactobacillus collinoides
• Lactobacillus gasseri (OLL2809, L13-Ia, ati SBT2055)
• Lactobacillus helveticus (NS8)
• Lactobacillus paracasei (NTU 101)
• Lactobacillus plantarum (C88, CAI6, FC225, SC4)
• Lactobacillus rhamnosus (GG)

Awọn afikun, Ewebe, ati awọn epo:

• Acetyl-L-Carnitine (ALCAR) ati Carnitine
• Allicin
• Alpha-lipoic acid
• Amentoflavone
• Andrographis paniculata
• Agmatine
• Apigenin
• Arginine
• Atishoki (Cyanropicrin)
• Ero
• Astragalus
• Bacopa
• Beefsteak (Isogemaketone)
• Berberine
• Beta-caryophyllene
• Bidens Pilosa
• Black Cumin Oil Oil (Thymoquinone)
• Boswellia
• Butein
• Butyrate
• Cannabidiol (CBD)
• Carotenioids (bii Beta-carotene [isopọ pẹlu Lycopene - 2 15 mg / d lycopene], Fucoxanthin, Zeaxanthin, Astaxanthin, ati Lutein)
• Chitrak
• Chlorella
• Chlorophyll
• Chrysanthemum zawadskii
• Cinnamomea
• Opo ti o wọpọ
• Ejò
• Coptis
• CoQ10
• Curcumin
• Damiana
• Dan Shen / Red Sage (Miltirone)
• DIM
• Dioscin
• Dong Ling Cao
• Dong Quai (ginseng obirin)
• Ecklonia Cava
• EGCG
• Elecampane / Inula
• Eucommia Bark
• Ferulic Acid
• Fisetin
• Epo Eja (DHA / EPA - 3 1 g / d epo ẹja ti o ni 1098 mg EPA ati 549 mg DHA)
• Galangal
• Gastrodin (Tian Ma)
• Gentiana
• Geranium
• Ginkgo Biloba (Ginkgolide B)
• Glasswort
• Gotu Kola
• Eso eso ajara fa
• Hairy Agrimony
• Ilọ (Triphala)
• Hawthorn
• Helichrysum
• Henna (Juglone)
• Hibiscus
• Higenamine
• Basil / Tulsi mimọ (Ursolic Acid)
• Hops
• Igbẹ koriko ti o korira (Icariin / Icariside)
• Indigo Naturalis
• Iron (kii ṣe iṣeduro ayafi ti o jẹ pataki)
• I3C
• Ibu Jobu
• Moringa Oleifera (bii Kaempferol)
• Inchinkoto (konbo ti Zhi Zi ati Wormwood)
• Kudzu Root
• Ilana alailẹgbẹ
• Lindera Gbongbo
• Luteolin (awọn aarọ giga fun titẹsi, awọn abere kekere ti dojuti NRF2 ni akàn tilẹ)
• Magnolia
• Manjistha
• Maximowiczianum (Acerogenin A)
• Mexico ni Arnica
• Wara Wara
• MitoQ
• Mu Xiang
• Mucuna Pruriens
• Nicotinamide ati NAD +
• Panax Ginseng
• Passionflower (bii Chrysin, ṣugbọn o le tun din NRF2 nipasẹ dysregulation ti PI3K / Akt signaling)
• Pau d arco (Lapacho)
• Phloretin
• Piceatannol
• PQQ
• Procyanidin
• Pterostilbene
• Pueraria
• Quercetin (awọn aarọ giga nikan, awọn abere kekere dẹkun NRF2)
• Qiang Huo
• Red Clover
• Resveratrol (Piceid ati awọn miiran phytoestrogens pataki, Knotweed)
• Oriṣiriṣi Soke
• rosewood
• Rutin
• Sappanwood
• Sarsaparilla
• Saururus chinensis
• SC-E1 (Gypsum, Jasmine, Licorice, Kudzu, ati Balloon Flower)
• Schisandra
• Ifarada ara ẹni (prunella)
• Skullcap (Baicalin ati Wogonin)
• Shepo Sorrel
• Si Wu Tang
• Sideritis
• Spikenard (Aralia)
• Spirulina
• St. John's Wort
• Sulforaphane
• Sutherlandia
• Tao Hong Si Wu
• Taurine
• Omi-ajara Oorun (Triptolide)
• Tocopherols (bii Vitamin E tabi Linalool)
• Ẹda R
• Tu Si Zi
• TUDCA
• Vitamin A (biotilejepe awọn miiran retinoids dena NRF2)
• Vitamin C (iwọn lilo giga nikan, iwọn lilo kekere ko ni inhib NRF2)
• Vitex / igi Igi
• Peony Pepe (Paeoniflorin lati Paeonia lactiflora)
• Wormwood (Hispidulin ati Artemisinin)
• Xiao Yao Wan (Free ati Easy Wanderer)
• Yerba Santa (Eriodictyol)
• Yuan Zhi (Tenuigenin)
• Zi Cao (yoo dinku NRF2 ni akàn)
• sinkii
• Ziziphus Jujube

Awọn Hormones ati awọn Neurotransmitters:

• Adiponectin
• Adropin
• Estrogen (ṣugbọn o le dinku NRF2 ni ideri igbaya)
• Melatonin
• Progesterone
• Acid Quinolinic (ni idaabobo idaabobo lati dènà iyara)
• Serotonin
• Awọn Hormones ti thyroid gẹgẹbi T3 (le mu NRF2 ṣe ni awọn ẹyin ti o ni ilera, ṣugbọn dinku rẹ ni akàn)
• Vitamin D

Oògùn / oogun ati kemikali:

• Acetaminophen
• Acetazolamide
• Amlodipine
• Auranofin
• Bardoxolone Methyl (BARD)
• Benznidazole
• BHA
• CDDO-imidazolide
• Ceftriaxone (ati awọn egboogi beta-lactam)
• Cialis
• Dexamethasone
• Aṣẹyọ (Awọn Iṣekọṣe)
• Eriodictyol
• Exendin-4
• Esetimibe
• Fluoride
• Fumarate
• HNE (oxidized)
• Idazoxan
• Arsenic inorganic ati sodium arsenite
• JQ1 (le ṣe idiwọ NRF2 bakanna, aimọ)
• Letairis
• Melphalan
• Methazolamide
• Methylene Blue
• Nifedipine
• NSAIDs
• Oltipraz
• Awọn PPI (bii Omeprazole ati Lansoprazole)
• Protandim - awọn esi nla ni vivo, ṣugbọn alailagbara / ti kii ṣe tẹlẹ ni nṣiṣẹ NRF2 ninu eniyan
• Probucol
• Rapamycin
• Reserpine
• Ruthenium
• Sitaxentan
• Awọn ofin (bii Lipitor ati Simvastatin)
• Tamoxifen
• Tang Luo Ning
• TBHQ
• Tecfidera (Dimethyl fumarate)
• THC (kii ṣe agbara bi CBD)
• Theophylline
• Umbelliferone
• Uidodeoxycholic Acid (UDCA)
• Verapamil
• Viagra
• 4-Acetoxyphenol

Awọn ọna ipa / Ifawejuwe Awọn Ofa:

• ? Nṣiṣẹ 7 nAChR
• AMPK
• Bilirubin
• CDK20
• CKIP-1
• CYP2E1
• Awọn EAATs
• Gankyrin
• Gremlin
• GJA1
• H-ferritin ferroxidase
• Awọn oludena adani HDAC (gẹgẹ bi awọn valproic acid ati TSA, ṣugbọn o le fa ailera NRF2)
• Omi Awọn ẹtan Amẹrika
• IL-17
• IL-22
• Klotho
• jẹ ki-7 (ṣubu mBach1 RNA)
• MAPK
• Michael gba awọn (julọ)
• miR-141
• miR-153
• miR-155 (ṣubu si isalẹ mBach1 RNA)
• miR-7 (ni ọpọlọ, iranlọwọ pẹlu akàn ati schizophrenia)
• Notch1
• Awọn ipalara ti o pọju (gẹgẹbi ROS, RNS, H2O2) ati awọn Electrophiles
• PGC-1?
• PKC-delta
• PPAR-gamma (awọn ipa ipilẹṣẹ)
• Sigma-1 gbigba idasile
• SIRT1 (mu ki NRF2 wa ninu ọpọlọ ati ẹdọforo sugbon o le dinku gbogbo rẹ)
• SIRT2
• SIRT6 (ninu ẹdọ ati ọpọlọ)
• SRXN1
• Idoju TrxR1 (attenuation tabi idinku bi daradara)
• Zinc protoporphyrin
• 4-HHE

Miiran:

• Ankaflavin
• Asbestos
• Avicins
• Bacillus amyloliquefaciens (lo ninu ogbin)
• Monoxide Erogba
• Daphnetin
• Idinku Glutathione (idinku ti 80% 90% ṣee ṣe)
• Koraiensis Gymnaster
• jedojedo C
• Ọpọn (HSV)
• India igi eeru
• Indigowoad Gbongbo
• Isosalipurposide
• Isorhamentin
• Monascin
• Omaveloxolone (lagbara, aka RTA-408)
• PDTC
• Isuna aifọkanla (aipe aipe aipe le mu NRF2)
• Siberian Larch
• Sophoraflavanone G
• Tadehagi triquetrum
• Ti o dara ju (7-DGD)
• Oju Iwoye
• 63171 ati 63179 (lagbara)

Apa ọna itọkasi 2 ipilẹṣẹ ohun-itanika 2, ti o mọ julọ nipasẹ acronym Nrf2, jẹ itọsi transcription eyi ti o ṣe ipa pataki ti iṣaṣaṣe awọn iṣakoso antioxidant aabo ti ara eniyan, paapaa lati ṣakoso itọju oxidative. Lakoko ti awọn ipele ti o pọ si ipalara ti o ni agbara ailera le mu Nrf2 ṣiṣẹ, awọn ipa rẹ ti ni ilọsiwaju pupọ nipasẹ niwaju orisirisi agbo ogun. Awọn ounjẹ ati awọn afikun ṣe iranlọwọ mu Nrf2 ṣiṣẹ ni ara eniyan, pẹlu isotiocyanate sulforaphane lati awọn ẹri broccoli. Dokita Alex Jimenez DC, CCST Insight

Sulforaphane ati Awọn ipa rẹ lori Akàn, Iku, Agbalagba, Ọpọlọ ati Ihuwasi, Arun Okan & Diẹ sii

Awọn isotiocyanates jẹ diẹ ninu awọn orisirisi ohun ọgbin ti o le ṣe pataki ninu ounjẹ rẹ. Ni fidio yi Mo ṣe akọsilẹ ti o ni julọ julọ fun wọn ti a ti ṣe. Igba kukuru kukuru? Foo si koko ayanfẹ rẹ nipa titẹ ọkan ninu awọn aaye ojuami isalẹ. Akoko ni kikun ni isalẹ.

Awọn abala bọtini:

• 00: 01: 14 - Akàn ati iyara
• 00: 19: 04 - Agbo
• 00: 26: 30 - Ẹmu ati iwa
• 00: 38: 06 - Ikẹhin atunṣe
• 00: 40: 27 - Iṣe

Akoko ni kikun:

• 00: 00: 34 - Ifihan ti sulforaphane, idojukọ pataki ti fidio.
• 00: 01: 14 - Lilo ikunkọ agbelebu ati awọn idinku ninu gbogbo iku-iku.
• 00: 02: 12 - Iwuro ti aisan ti ẹjẹ.
• 00: 02: 23 - Awọn ewu iṣan akàn.
• 00: 02: 34 - Egungun ti aisan ninu awọn ewu ti nmu taba.
• 00: 02: 48 - Ewu aarun igbaya ara ọmọ.
• 00: 03: 13 - Aapọ: kini o ba ti ni akàn? (intervention)
• 00: 03: 35 - Ẹrọ ti o lewu ti n ṣaisan akàn ati awọn data ti n ṣaṣepọ ti n ṣanṣe.
• 00: 04: 38 - Sulforaphane ati akàn.
• 00: 05: 32 - Awọn ẹri eranko ti n han ipa ti broccoli sprout jade lori apo iṣan idagbasoke ni awọn eku.
• 00: 06: 06 - Ipa ti imikun afikun ti sulforaphane ninu awọn alaisan alaisan to somọ apo.
• 00: 07: 09 - Isọpọ awọn metabolites ti isothiocyanate ninu awọ ara omu gangan.
• 00: 08: 32 - Idinku ti aarun igbaya ti nmu awọn ẹyin.
• 00: 08: 53 - Itan igbasilẹ: awọn idilẹ braicas ni a ti fi idi mulẹ bi nini awọn ẹya ilera ni Ilu Romu atijọ.
• 00: 09: 16 - Agbara Sulforaphane lati mu idarini ti ọdaràn ṣe (benzene, acrolein).
• 00: 09: 51 - NRF2 gegebi iyipada jiini nipasẹ awọn ero idaamu ti ẹda.
• 00: 10: 10 - Bawo ni NRF2 ṣiṣẹsi mu ki iṣan ti o ni ipa nipasẹ glutathione-S-conjugates.
• 00: 10: 34 - Brussels sprouts mu glutathione-S-transferase ati dinku DNA ibajẹ.
• 00: 11: 20 - Ohun mimu kukisi Broccoli mu alekun bii benzene nipasẹ 61%.
• 00: 13: 31 - Kokoro Broccoli sprogen pọ si mu awọn enzymes ti ajẹsara ni oke afẹfẹ oke.
• 00: 15: 45 - Agbejade ikunwọ agbelebu ati arun aisan okan.
• 00: 16: 55 - Broccoli sprout lulú ṣe iṣeduro ẹjẹ ati ailera arun okan ni iru 2 diabetics.
• 00: 19: 04 - Bẹrẹ ti apakan ti ogbologbo.
• 00: 19: 21 - Sulforaphane-Enriched onje mu igbesi aye ti beetles lati 15 si 30% (ni awọn ipo).
• 00: 20: 34 - Pataki ti iredodo kekere fun longevity.
• 00: 22: 05 - Awọn ẹfọ ikoko ati brokoli koriko fẹrẹ jẹ lati dinku awọn ami-ẹri ti awọn ẹmi-ara ẹni ni awọn eniyan.
• 00: 23: 40 - Ayẹwo fidio ti aarin-fidio: akàn, awọn ipin ti ogbologbo
• 00: 24: 14 - Awọn irọ-sisin fihan wipe sulforaphane le ṣe atunṣe iṣẹ imunaduro ti ko dara ni ọjọ ogbó.
• 00: 25: 18 - Sulforaphane ṣe itesiwaju irun ori irun-awọ ninu irun-awọ ti balding. Aworan ni 00: 26: 10.
• 00: 26: 30 - Bibẹrẹ ti opolo ati abala ihuwasi.
• 00: 27: 18 - Ipa ti itọlẹ broccoli lori autism.
• 00: 27: 48 - Ipa ti glucoraphanin lori schizophrenia.
• 00: 28: 17 - Ibẹrẹ ifọrọwọrọ inu iṣoro (iṣiro ti o ṣee ṣe ati awọn ẹkọ).
• 00: 31: 21 - Iwa jiwe nipa lilo awọn ẹya oriṣiriṣi 10 ti awọn ailera ti o ni wahala ṣe afihan sulforaphane bakannaa o wulo bi fluoxetine (prozac).
• 00: 32: 00 - Iwadi fihan itọsọna taara ti glucoraphanin ninu awọn eku jẹ bakannaa ti o munadoko ni idena ibanujẹ lati apẹẹrẹ itọju agbara ikọlu.
• 00: 33: 01 - Ibẹrẹ ti apakan apakan.
• 00: 33: 30 - Sulforaphane ati arun Alzheimer.
• 00: 33: 44 - Sulforaphane ati arun aisan Parkinson.
• 00: 33: 51 - Sulforaphane ati arun Hungtington.
• 00: 34: 13 - Sulforaphane mu ki awọn ọlọjẹ-mọnamọna ti o gbona.
• 00: 34: 43 - Bẹrẹ iṣan ipalara iṣan ara iṣan.
• 00: 35: 01 - Sulforaphane ti rọ lẹsẹkẹsẹ lẹhin TBI ṣe iranti (iṣọ asin).
• 00: 35: 55 - Sulforaphane ati eleyii ti nmu.
• 00: 36: 32 - Sulforaphane n mu ẹkọ dara ni awoṣe ti aisan II ti o wa ninu awọn eku.
• 00: 37: 19 - Sulforaphane ati duchenne muscular dystrophy.
• 00: 37: 44 - Idinku ibanuwọn ninu awọn sẹẹli satẹlaiti iṣọn (in vitro).
• 00: 38: 06 - Ipalara ti akoko-fidio: iku ati akàn, ibajẹ DNA, iṣiro ti aiṣedede ati iredodo, itọsi benzene, arun inu ọkan ati ẹjẹ, oriṣi II, ipalara lori ọpọlọ (ibanujẹ, autism, schizophrenia, neurodegeneration), NRF2 ọna.
• 00: 40: 27 - Awọn ero lori ṣafihan iyọọda broccoli tabi sulforaphane.
• 00: 41: 01 - Awọn ayokele lori sprouting ni ile.
• 00: 43: 14 - Lori sise awọn iwọn otutu ati iṣẹ aṣayan sulforaphane.
• 00: 43: 45 - Gut kokoro iyipada ti sulforaphane lati glucoraphanin.
• 00: 44: 24 - Awọn afikun yoo ṣiṣẹ daradara nigbati o ba darapọ pẹlu iṣiro lọwọ lati ẹfọ.
• 00: 44: 56 - Awọn ilana sise sise ati awọn ẹfọ cruciferous.
• 00: 46: 06 - Awọn isotiocyanates bi goitrogens.

Gẹgẹbi ọpọlọpọ awọn iwadii iwadii lọwọlọwọ, ọna iparun ifihan agbara 2 ti o ni ibatan erythroid 2 ti o ni ibatan ifosiwewe, ti o dara julọ ti a mọ ni Nrf2, jẹ ifosiwewe transcription eyiti o mu awọn sẹẹli 'awọn ilana alaabo aabo ṣiṣẹ lati sọ ara eniyan dibajẹ lati awọn ita ita ati ti inu ati ṣe idiwọ alekun awọn ipele ti aapọn ipanilara. Dopin ti alaye wa ni opin si chiropractic ati awọn ọran ilera eegun ẹhin. Lati jiroro ọrọ naa, jọwọ ni ọfẹ lati beere lọwọ Dokita Jimenez tabi kan si wa at us915-850-0900 .

Ti a da nipasẹ Dr. Alex Jimenez

Ifọrọwerọ Koko-ọrọ Afikun: Pain Irora Pada Pada

Ideri afẹyintiOne jẹ ọkan ninu awọn idi ti o wọpọ julọ ti ailera ati awọn ọjọ ti o padanu ni iṣẹ ni kariaye. Awọn abuda irora pada si idi keji ti o wọpọ julọ fun awọn abẹwo ọfiisi dokita, ti o pọ ju nikan nipasẹ awọn akoran atẹgun oke. O fẹrẹ to 80 ogorun ninu olugbe yoo ni iriri irora irora o kere ju lẹẹkan ni gbogbo igbesi aye wọn. Ọpa-ẹhin jẹ ẹya ti o nira ti o jẹ awọn egungun, awọn isẹpo, awọn iṣọn ara, ati awọn iṣan, laarin awọn awọ asọ miiran. Awọn ọgbẹ ati / tabi awọn ipo ti o buru si, bii Awọn ẹkunrẹrẹ ti a fi sinu rẹ, le bajẹ ja si awọn aami aiṣan ti irora pada. Awọn ipalara ere idaraya tabi awọn ipalara ijamba mọto ayọkẹlẹ nigbagbogbo jẹ idi ti o wọpọ julọ ti ibanujẹ pada, sibẹsibẹ, nigbakan awọn iṣipopada ti o rọrun julọ le ni awọn abajade irora. Ni akoko, awọn aṣayan itọju miiran, gẹgẹbi itọju chiropractic, le ṣe iranlọwọ irorun irora pada nipasẹ lilo awọn atunṣe ọpa-ẹhin ati awọn ifọwọyi ni ọwọ, ni ipari imudarasi irora.

Pupọ Tita | NIPA TITUN: Ti ṣe iṣeduro El Paso, TX Chiropractor

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